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目的:观察应用奥沙利铂联合治疗晚期大肠癌的近期疗效及毒副反应。方法:72例晚期大肠癌随机分为两组,一组为治疗组,奥沙利铂联合5-Fu/CF;另一组为对照组5-Fu/CF。结果:治疗组有效率52.8%,对照组有效率30.6%,有显著性差异(P<0.05)。毒副反应主要是恶心、呕吐、贫血和感觉神经毒性,对白细胞和血小板影响较小。结论:奥沙利铂联合5-Fu/CF,治疗晚期大肠癌有效而安全。
Objective: To observe the short-term curative effect and toxicity of oxaliplatin in the treatment of advanced colorectal cancer. Methods: Seventy-two patients with advanced colorectal cancer were randomly divided into two groups. One was treated with oxaliplatin combined with 5-Fu / CF and the other was 5-Fu / CF. Results: The effective rate was 52.8% in the treatment group and 30.6% in the control group, with significant difference (P <0.05). Toxic side effects are mainly nausea, vomiting, anemia and sensory neurotoxicity, less effect on white blood cells and platelets. Conclusion: Oxaliplatin combined with 5-Fu / CF is effective and safe in the treatment of advanced colorectal cancer.