电压门控性氯离子通道在细胞膜电位、细胞容积调节、细胞器酸化及细胞增殖、凋亡等生理过程中发挥重要作用,电压门控性氯离子通道家族由两个相同孔道所构成的同源二聚体膜蛋白组成,具有典型的“双筒枪”结构模式。近年研究发现电压门控性氯通道与肿瘤细胞的增殖、凋亡、侵袭及多药耐药性等恶性生物学行为有关。随着进一步的探索,电压门控性氯通道有望成为抗肿瘤治疗的新靶点。 The voltage-gated chloride channel plays an important role in the physiological processes such as cell membrane potential, cell volume regulation, organelle acidification and cell proliferation and apoptosis. The voltage-gated chloride channel family consists of two homologous two Membrane protein composition, with a typical “double barrel gun ” structure mode. Recent studies have found that voltage-gated chloride channels are associated with malignant biological behaviors such as proliferation, apoptosis, invasion and multidrug resistance in tumor cells. With further exploration, voltage-gated chloride channel is expected to become a new target for anti-tumor therapy.