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目的 研究补硒对预防原发性肝癌的作用。方法 检测男性 2 0～ 6 5岁 180 0 0人 ,检出HBsAg(+ )、AFP(- )、肝功能 (ALT)基本正常的患者 2 0 6 5例 ,按地区随机分为补硒组 1112例及对照组95 3例。补硒组每人每天服亚硒酸钠 1片 0 5mg,对照组服安慰剂 1片。前瞻观察 3年。结果 补硒组血硒显著升高 ,相应谷胱甘肽过氧化酶随之升高 ;相反外周血淋巴细胞微核检出率补硒组低于对照组。肝癌发病率补硒组 3 0 5 7 5 5 /10万 (34/1112 ) ,对照组 5 981 11/10万 (5 7/95 3)。结论 补硒方法简单 ,易以推广。在肝癌高发区高危人群中 ,尤其是低硒地区 ,补硒可以预防肝癌
Objective To study the effect of selenium supplementation on prevention of primary liver cancer. Methods A total of 2 065 patients with HBsAg (+ ), AFP (-) and liver function (ALT) were detected. The patients were randomly divided into selenium group 1112 by area. Cases and control group 95 3 cases. The selenium supplement group received 1 tablet of sodium selenite per day for 0 5 mg, and the control group received 1 placebo. Look forward to 3 years. Results Selenium in selenium supplementation group increased significantly and the corresponding glutathione peroxidase increased. On the contrary, the detection rate of peripheral blood lymphocyte micronucleus was lower in the selenium supplement group than in the control group. The incidence of hepatocellular carcinoma was 3 0 5 7 5 5 /10 million (34/1112), and the control group was 5 981 11/10 million (5 7/95 3). Conclusion Selenium supplementation method is simple and easy to promote. In high-risk populations with high incidence of liver cancer, especially in areas with low selenium, selenium supplementation can prevent liver cancer