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为了制备功能化的栓塞微球,提高微球的载药率,以海藻酸钠(SA)为起始原料,经牛磺酸(TA)改性,采用反相乳液聚合方法将改性后的产物制得栓塞微球。用扫描电子显微镜(SEM)、超景深显微镜、紫外/可见分光光度计等对微球进行了鉴定和表征,并测定了改性前后SA水溶液的黏度。结果表明:改性后的SA溶液在水中的黏度有所降低;微球直径100~500μm;与未改性聚合物相比,改性后的SA微球负载药物阿霉素最高达到30%;载药微球对药物阿霉素的累计释放量增加,缓释现象明显。
In order to prepare functionalized embolic microspheres and improve the drug loading rate of the microspheres, sodium alginate (SA) was used as starting material and modified by taurine (TA). The modified Products obtained embolic microspheres. The microspheres were identified and characterized by scanning electron microscopy (SEM), ultra-depth-of-field microscopy, ultraviolet / visible spectrophotometer and the viscosity of SA aqueous solution before and after modification. The results showed that the viscosity of modified SA solution decreased in water; the diameter of microspheres was 100-500μm; compared with unmodified polymer, modified SA microspheres loaded doxorubicin up to 30%; Drug-loaded microspheres increased the cumulative release of doxorubicin drug, sustained release was obvious.