论文部分内容阅读
近年新发现的跨膜趋化因子CXCL16既具有趋化因子的功能,可以趋化激活的T淋巴细胞,促进T细胞与抗原递呈细胞的作用,同时还可作为清道夫受体吞噬氧化型低密度脂蛋白,促进泡沫细胞形成,此外CXCL16还有促进平滑肌细胞、内皮细胞增殖,增加细胞与细胞黏附的作用,动脉粥样硬化斑块处巨噬细胞和平滑肌细胞CX-CL16表达增高,因此CXCL16可能在多个环节参与动脉粥样硬化的发生、发展。
In recent years, the newly discovered transmembrane chemokine CXCL16 not only has the function of chemokines, chemotactic activated T lymphocytes, promote the role of T cells and antigen presenting cells, but also as scavenger receptor phagocytic oxidative low Density lipoprotein, promote the formation of foam cells, in addition CXCL16 also promote smooth muscle cells, endothelial cell proliferation, increase the role of cells and cell adhesion, atherosclerotic plaque at the macrophages and smooth muscle cells CX-CL16 expression increased, CXCL16 May participate in the occurrence and development of atherosclerosis in many aspects.