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采用单相动作电位记录技术研究蝙蝠葛苏林碱 (DS)对家兔在体心脏单相动作电位 (MAP)作用的使用依赖性特征 .结果显示DS在 2 4 0 ,2 10 ,180ms起搏周长 (CL)均能降低MAP振幅 (MAPA) ,延长MAP复极达 50 %和 90 %的时程 (MAPD50 ,MAPD90 ) ,有效不应期 (ERP)和ERP/MAPD90 .延长MAPD50 百分率分别为 12 .8± 2 .9,9.5± 2 .6 ,9.0± 1.6 ,延长MAPD90 百分率分别为 10 .9± 2 .6 ,7.5± 2 .4 ,6 .5±2 .7,延长ERP百分率分别为 2 5.7± 4 .3,18.5±4 .1,2 4 .2± 7.2 ,延长ERP/MAPD90 百分率分别为13.7± 4 .5,10 .2± 2 .2 ,16 .1± 5.1(P >0 .0 5) .其延长作用均呈非使用依赖性特征 .在所有起搏周长下 ,索他洛尔亦降低MAPA ,延长MAPD50 ,MAPD90 ,ERP ,ERP/MAPD90 ,但其延长MAPD90 ,ERP的作用均呈逆向使用依赖性特征 (P <0 .0 5) .结果表明 ,DS能明显降低家兔在体心脏MAPA ,延长MAPD50 ,MAPD90 ,ERP ,ERP/MAPD90 ,该作用呈非使用依赖性特征 .
Single-phase action potential recording technique was used to study the dependence dependence of daurisoline (DS) on the single-phase action potential (MAP) of the rabbit heart in vivo. The results showed that the DS at 240, 2500, (MAP) could prolong MAP repolarization up to 50% and 90% (MAPD50, MAPD90), effective refractory period (ERP) and ERP / MAPD90, respectively. 8 ± 2.9, 9.5 ± 2.6 and 9.0 ± 1.6, respectively. The percentages of prolonged MAPD90 were 10.9 ± 2.6, 7.5 ± 2.4, 6.5 ± 2. ± 4 .3, 18.5 ± 4 .1, 24.2 ± 7.2, and the percentage of prolonged ERP / MAPD90 were 13.7 ± 4 .5,10 .2 ± 2 .2 and 16.1 ± 5.1 (P> 0 .0 Soxanalol also decreased MAPA, prolonged MAPD50, MAPD90, ERP, ERP / MAPD90, but prolonged MAPD90, ERP both in all pacing circumference (P <0.05). The results showed that DS could significantly reduce MAPK, MAPD90, ERP and ERP / MAPD90 in heart of rabbits, which was non-use-dependent.