论文部分内容阅读
目的通过分析3例淋巴细胞性间质性肺炎(LIP),探讨LIP的病因、诊断及鉴别诊断。方法回顾性分析我院确诊的3例LIP患者的临床特点,并结合文献报道加以总结。结果(1)LIP常与自身免疫性疾病和免疫缺陷相关,起病缓慢,主要表现为进行性咳嗽和呼吸困难,双肺底听诊可闻及爆裂音,肺功能常表现为限制性通气功能障碍伴弥散功能受损。(2)高分辨率CT表现为边界不清的小叶中央性结节和胸膜下小结节、磨玻璃样影,支气管血管束增厚、小叶间隔增厚及囊状气腔。(3)支气管肺泡灌洗液中淋巴细胞增多。(4)病理表现为弥漫性肺间质致密淋巴细胞浸润,淋巴细胞呈多克隆性。结论特发性LIP罕见,若要确诊应进行全面检查以明确有无任何已知的病因或相关疾病。
Objective To analyze the etiology, diagnosis and differential diagnosis of LIP by analyzing 3 cases of lymphocytic interstitial pneumonia (LIP). Methods The clinical features of 3 cases of LIP diagnosed in our hospital were retrospectively analyzed and summarized in the literature. Results (1) LIP often associated with autoimmune diseases and immune deficiency, slow onset, mainly manifested as progressive cough and breathing difficulties, lung auscultation may be heard and crackles, pulmonary function often manifested as restrictive ventilation dysfunction With diffuse dysfunction. (2) High-resolution CT showed unclear lobular central nodules and small subpleural nodules, ground glass-like shadow, thickening of bronchovascular bundles, thickening of interlobular septa and cystic air cavity. (3) bronchoalveolar lavage fluid lymphocytosis. (4) pathological manifestations of diffuse pulmonary interstitial dense lymphocyte infiltration, polyclonal lymphocytes. Conclusions Idiopathic LIP is rare, and if confirmed, a complete examination should be performed to determine whether there is any known cause or related disease.