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目的:比较地特胰岛素与甘精胰岛素治疗早期2型糖尿病的疗效。方法:50例早期初发2型糖尿病患者(7.0≤空腹血糖≤13.9 mmol·L~(-1))随机分为治疗组(给予地特胰岛素)和对照组(给予甘精胰岛素),均按初始剂量0.2 u·kg~(-1)·d~(-1),ih,qd。比较两组治疗前后血糖、血糖达标时间、胰岛素用量和低血糖发生率。结果:两组治疗前糖化血红蛋白、血糖及胰岛素分泌差异无统计学意义(P<0.05),治疗后血糖均明显下降(P<0.01);治疗组较对照组血糖达标时间短(P<0.01),胰岛素用量及低血糖发生率均减少(P<0.05)。结论:地特胰岛素是治疗早期2型糖尿病有效的基础胰岛素。
Objective: To compare the efficacy of insulin detemir and insulin glargine in the treatment of early type 2 diabetes mellitus. Methods: Fifty patients with early-onset type 2 diabetes mellitus (7.0 ≤ fasting glucose ≤13.9 mmol · L -1) were randomly divided into treatment group (given insulin detemir) and control group (given insulin glargine) The initial dose of 0.2 u · kg -1 (-1) · d -1, ih, qd. Before and after treatment, blood glucose, blood glucose compliance time, insulin dosage and incidence of hypoglycemia were compared. Results: Before treatment, there was no significant difference in HbA1c, blood glucose and insulin secretion between the two groups (P <0.05), and the blood glucose was significantly decreased after treatment (P <0.01); the treatment group was shorter than the control group (P <0.01) , Insulin dosage and incidence of hypoglycemia were decreased (P <0.05). Conclusion: Detemir insulin is an effective basal insulin for the treatment of early type 2 diabetes.