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目的 总结1例成人肝脏纤维组织细胞瘤多次复发并伴有破裂出血患者的诊治经过及经验.方法 回顾性分析中国医科大学附属盛京医院于2018年5月收治的1例在术前行MDT讨论的复发性成人纤维组织细胞瘤伴破裂出血患者的资料,对该患者多次复发破裂出血的原因以及诊治经验进行总结分析.结果 该患者曾行2次手术,一般情况良好,经影像科、肿瘤科、介入科和肝胆外科医师多学科讨论后,认为行手术治疗为最佳治疗方案.与患者及家属充分沟通后,选择了开腹肿瘤切除术,手术顺利.手术时间278min,术中出血约100mL,未输血.术后无出血、腹腔感染、胃瘫等并发症发生,于术后第13天顺利出院.第3次术后已获访8个月,术后6个月时肿瘤再次复发,口服甲磺酸阿帕替尼片行靶向治疗1个月余,继续随访治疗效果.结论 复发性成人纤维组织细胞瘤伴破裂出血临床罕见,治疗主要以手术切除为基础,术后结合包括放化疗、分子靶向以及免疫药物治疗在内的综合治疗,其近期疗效较满意,远期疗效还需进一步观察.“,”Objective To summarize the experience of diagnosis and treatment of a case of adult hepatic fibrohistiocytoma with recurrent rupture and hemorrhage.Methods Retrospective analysis on this case of recurrent adult fibrohistiocytoma with rupture and hemorrhage admitted to Shengjing Hospital Affiliated to China Medical University in May 2018 was conducted,discussion on MDT was conducted before surgery,and the causes of recurrent rupture and hemorrhage,as well as the experience of diagnosis and treatment were summarized and analyzed.Results This patient was generally in good condition.After MDT discussions among the imaging department,oncology department,interventional department,and hepatobiliary surgeons,it was considered that surgical treatment was the best treatment scheme.After full communication with the patient and his family,the patient had chosen open tumor resection and the operation was smooth.The operation time was 278 min,intraoperative bleeding was about 100 mL,and no blood transfusion was performed.No bleeding,abdominal infection,gastroparesis,and other complications occurred after the operation,and the patient was discharged successfully on the 13th day after the operation.The patient had been interviewed for 8 months and the tumor recurred again 1 month ago.Currently,oral apatinib had been targeted for treatment for more than 1 month,and the follow-up treatment continued.Conclusions Recurrent adult fibrous histiocytoma with rupture and hemorrhage is rare in clinical practice,and the treatment is mainly based on surgical resection.Postoperative comprehensive treatment combined with radiotherapy,chemotherapy,molecular targeting,and immunotherapy is the main treatment.Its short-term efficacy is satisfactory,but long-term efficacy still needs to be further observed.