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目的探讨吸入皮质激素对哮喘儿童性激素的影响。方法采用SEROZYME酶联免疫测定仪,测定31名哮喘儿童(观察组)和50名健康儿童(对照组)血清雌二醇(E2)、睾酮(T)、卵泡刺激素(FSH)、黄体生成素(LH)四项指标。观察组在开始吸入皮质激素前和吸入后6个月进行两次采血测定。结果哮喘患儿的E2、T较高,与正常儿童比较有显著性差异;患儿在规则吸入皮质激素治疗6个月后,血清E2、T、LH、FSH与治疗前相比无显著性差异。结论常规剂量吸入皮质激素治疗对哮喘儿童性激素的影响并不明显。
Objective To investigate the effects of inhaled corticosteroids on sex hormones in asthmatic children. Methods Serum estradiol (E2), testosterone (T), follicle stimulating hormone (FSH), luteinizing hormone (FSH) were measured in 31 asthmatic children (observation group) and 50 healthy children (control group) using SEROZYME enzyme- (LH) four indicators. The observation group performed two blood tests two months prior to the start of inhaled corticosteroids and six months after inhalation. Results The levels of E2 and T in asthmatic children were higher than those in normal children. There was no significant difference in serum E2, T, LH and FSH between 6 months after routine inhaled corticosteroid treatment . Conclusion The effect of conventional dose inhaled corticosteroids on sex hormones in asthmatic children is not obvious.