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目的探讨治疗前外周血中性粒细胞与淋巴细胞比值(neutrophil-to-lymphocyte ratio,NLR)与小细胞肺癌患者预后的关系。方法回顾性分析2013年1月~2015年3月安徽医科大学第一附属医院病理诊断明确的50例小细胞肺癌患者,所有患者未行手术治疗,以NLR中位数将患者分为高NLR组和低NLR组,对可能影响患者预后的各项因素进行分析。结果 47例病人获得随访。47例患者中1年生存率为53.2%。其中低NLR组的病人1年生存率为83.3%;高NLR组病人1年生存率为21.7%,单因素分析显示小细胞肺癌患者的预后与患者的分期、体力状况ECOG评分以及NLR水平相关(均有P<0.05),对与预后相关的变量进行COX多因素分析,结果显示分期处于广泛期和高NLR水平是影响患者预后的独立危险因素(均有P<0.05)。结论 NLR可能是小细胞肺癌患者预后的独立危险因素。
Objective To investigate the relationship between neutrophil-to-lymphocyte ratio (NLR) and the prognosis of patients with small cell lung cancer before treatment. Methods A retrospective analysis of 50 patients with SCLC diagnosed in the First Affiliated Hospital of Anhui Medical University from January 2013 to March 2015 was performed. All the patients were treated without surgery. The patients were divided into high NLR group And low NLR group, the factors that may affect the prognosis of patients were analyzed. Results 47 patients were followed up. The one-year survival rate was 53.2% in 47 patients. The 1-year survival rate of patients with low NLR was 83.3%. The 1-year survival rate of patients with high NLR was 21.7%. Univariate analysis showed that the prognosis of patients with small cell lung cancer was related to the staging of patients, ECOG scores of physical status and the level of NLR (P <0.05). COX-multivariate analysis showed that the prognosis-related variables were independent risk factors for prognosis in patients with extensive stage and high NLR (all P <0.05). Conclusion NLR may be an independent risk factor for the prognosis of patients with small cell lung cancer.