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目的比较国产动脉导管未闭封堵器与Amplatzer封堵器(美国进口)在经动脉导管未闭(PDA)封堵术中应用的疗效。方法对2006年1月至12月广东省人民医院确诊为PDA的206例患者,110例采用国产封堵器,96例采用Amplatzer封堵器,分别进行PDA封堵术,对比两组的疗效、并发症和费用等情况。结果国产组109例封堵成功(成功率99.1%),进口组95例封堵成功(成功率99.0%)。两组PDA术前各项临床资料指标、手术和X线曝光时间、封堵成功率及住院天数、术后各项并发症发生率比较,差异无显著性意义,两组PDA治疗前后左室舒张末压及心胸比率降低程度差异无显著性意义,治疗总费用国产组明显低于进口组。结论国产PDA封堵器与Amplatzer封堵器相比其疗效、并发症发生率差异无显著性意义,治疗费用低,临床应用前景广泛。
Objective To compare the curative effect of domestic patent ductus arteriosus occluder and Amplatzer occluder (United States import) in transcatheter closure of patent ductus arteriosus (PDA). Methods From January 2006 to December 2006, 206 patients diagnosed as PDAs in Guangdong Provincial People’s Hospital were enrolled. One hundred and ten patients received domestic occluder and 96 patients received Amplatzer occluder. PDA occlusion was performed respectively. The curative effect was compared between the two groups. Complications and costs and so on. Results In the 109 cases, the successful occlusion was successful in domestic group (success rate was 99.1%), and 95 cases in the imported group were successfully occluded (success rate was 99.0%). There were no significant differences between the two groups in the clinical data before operation, the time of operation and X-ray exposure, the success rate of occlusion and days of hospitalization, and the incidence of postoperative complications. There was no significant difference between the two groups before and after PDA treatment There was no significant difference between the end-pressure reduction and thoracic-cardiac rate reduction. The total cost of treatment in the domestic group was significantly lower than that of the import group. Conclusion Compared with Amplatzer occluder, the PDA occluder made in China has no significant difference in the incidence of complications and complications. The treatment cost is low and the clinical application is promising.