现已知我国半数地区存在着姬鼠和家鼠二种型别的肾综合征出血热(HFRS)的混合流行,因此,有必要研制能同时预防这二种型别的疫苗。目前我国用于生产的三株HFRS病毒,对同型各毒株均表现较好的中和作用,但对异型病毒的交叉中和作用较差。经人体免疫三针后,对同型病毒的中和抗体阳转率可达90%,而对异型病毒的阳转率仅30%。因而,在我国,研制双价HFRS灭活疫苗免疫的工作早已被提出来了。 It is now known that there is a mixed epidemic of two types of Apodemus aguascteri and Hemoglobin fever (HFRS) in half of China’s regions. Therefore, it is necessary to develop a vaccine that can simultaneously prevent both types of HFRS. At present, the three HFRS viruses used in the production of our country have a good neutralization effect on all strains of the same type, but their cross-neutralization effects on the heterotypic viruses are poor. After three doses of human immunization, positive rate of neutralizing antibody to the same type of virus can reach 90%, while positive rate of heterotypic virus is only 30%. Therefore, in our country, the work of developing immunization of bivalent HFRS inactivated vaccine has already been put forward.