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从13α-醋酸去氢表雄酮经7步反应得到13α-雌甾-4-烯-3,17-二酮,随后在丁基锂中进行17-位加成得到其17位衍生物,同时还合成了这些化合物的13β差向异构体以比较其在各方面的差异,并以放射受体分析法测定了这些化合物与孕酮受体的相对亲合力。
13α-Estol-4-ene-3,17-dione is obtained from 13α-dehydroepiandrosterone in 7 steps followed by 17-position addition in butyllithium to give its 17-position derivative while The 13β epimers of these compounds were also synthesized to compare their differences in various aspects and the relative affinities of these compounds to progesterone receptors were determined by radioreceptor assays.