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应激作为心律失常的重要诱因及病因之一,其对心肌细胞的影响可通过多种不同途径和机制。不同类型的应激状态可导致全身自主神经系统失衡、激素改变,细胞的损伤和凋亡,钙离子通道异常等,而促发疾病的发生。近年来,有关心律失常发生机制的研究发现:缝隙连接蛋白43在结构和功能上的改变与应激下心律失常的发生关系密切。交感或迷走神经过度兴奋时的应激状态将影响缝隙连接蛋白43表达和分布的变化,从而导致缝隙连接蛋白43去磷酸化,促使心律失常的发生。
Stress as an important cause and cause of arrhythmia, its impact on myocardial cells through a variety of different ways and mechanisms. Different types of stress conditions can lead to systemic autonomic nervous system imbalance, hormonal changes, cell damage and apoptosis, abnormalities of calcium channels, and so on, to trigger the occurrence of the disease. In recent years, studies on the mechanism of arrhythmia have found that the structural and functional changes of connexin 43 are closely related to the occurrence of arrhythmia under stress. The stress state during sympathetic or vagal hyperexcitability will affect the changes in the expression and distribution of connexin 43, leading to the dephosphorylation of connexin 43 and the induction of cardiac arrhythmias.