健康雄性Wistar大鼠12只,其中6只作为对照,其余6只每天肌肉注射地塞米松磷酸盐0.6mg(0.3ml)连续7天,于末次注射后24小时杀死取材,分别对心脏和肝脏做组织学、组化及超微结构观察。注射地塞米松后,动物体重下降,肝重和心重皆增加。实验动物肝细胞浊肿,部分呈脂肪变性,细胞核固缩乃至崩溃。糖元及中性脂肪含量增多,非特异性酯酶活 Twelve healthy male Wistar rats were used as controls, 6 of them were served as control. The other 6 rabbits were intramuscularly injected with 0.6 mg (0.3 ml) of dexamethasone phosphate for 7 consecutive days. The animals were sacrificed at 24 hours after the last injection, Histology, histochemistry and ultrastructure observation. After injection of dexamethasone, animals lost weight, liver weight and heart weight increased. Experimental animal hepatocyte turbidity, some were fatty degeneration, nuclear shrinkage and collapse. Glycogen and neutral fat content increased, non-specific esterase activity