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[目的 ]探讨镉接触与肾小管功能障碍的关系 ,为寻求镉致早期肾损害的指标提供依据。 [方法 ]选取某锌品厂的工人 110名为镉接触组 ,以当地商业人员为对照 ,观察了镉摄入量、尿镉含量与 β2 微球蛋白、视黄醇结合蛋白和白蛋白排出量的关系。 [结果 ]当镉总摄入量和尿镉分别超过 5 0mg和 5 μg/g肌酐后 ,尿 β2 微球蛋白、视黄醇蛋白和白蛋白的排出量以及异常率相继升高 ,并呈现明显的剂量 效应关系 ,其中 β2 微球蛋白尿最先出现 ,白蛋白尿出现甚晚。 [结论 ]尿 β2 微球蛋白和视黄醇蛋白可较敏感地反映镉致肾损害。
[Objective] To investigate the relationship between cadmium exposure and renal tubular dysfunction and provide the basis for the index of seeking early renal damage caused by cadmium. [Method] A total of 110 workers in a zinc factory were selected as the cadmium exposure group. The local commercial staff were used as the control. Cadmium intake, urinary cadmium content, β2 microglobulin, retinol binding protein and albumin output Relationship. [Results] The urinary β2-microglobulin, retinol and albumin excretion and abnormalities of urinary cadmium, urine cadmium and urinary cadmium exceeded 50 mg and 5 μg / g respectively Dose-response relationship, in which β2 microglobulinuria first appeared, albuminuria appeared late. [Conclusion] Urinary β2 microglobulin and retinal protein can reflect cadmium - induced renal damage more sensitively.