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血小板对冠状动脉粥样硬化及其合并症的形成超重要作用。动脉粥样硬化患者血小板消耗增加,由于血小板在动脉内膜上粘附、聚集后释放出生长因子,这是动脉粥样硬化的主要病理改变。给猿喂以致动脉粥样硬化的食物,可导致血小板消耗量增加,最后引起与人相似的动脉粥样硬化。如同时给以血小板抑制性药物,如阿斯匹林、潘生丁,可以阻止血小板消耗,从而防止动脉壁平滑肌细胞增生及动脉粥样硬化的形成。近数年来,不少学者,在致力于基础研究的同时,还作了大量抗血小板药物筛选,最佳剂量的调整,前瞻性大数量病例临床验证。兹将有关进展,综述于后。花生四稀酸代谢前列环素(PGI_2)及血栓素A_2(TXA_4),虽
Platelet plays a very important role in the formation of coronary atherosclerosis and its complications. Patients with atherosclerosis increased platelet consumption, due to platelet adhesion in the arterial intima, the release of growth factors after aggregation, which is the main pathological changes in atherosclerosis. Feeding atherosclerosis to the ape can result in an increase in platelet consumption and eventually a similar atherosclerosis in humans. If given to platelet inhibitory drugs, such as aspirin, dipyridamole, can prevent platelet consumption, thereby preventing arterial wall smooth muscle cell proliferation and atherosclerosis formation. In recent years, many scholars, while devoted to basic research, also made a large number of anti-platelet drug screening, the optimal dose adjustment, prospective large number of clinical validation. The relevant progress will be summarized later. Arachidonic acid metabolism of prostacyclin (PGI_2) and thromboxane A_2 (TXA_4), although