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目的:观察复方蓼大青叶口服液治疗儿童急性上呼吸道感染的疗效及安全性。方法:将123例急性上呼吸道感染患儿随机按数字法分为治疗组62例和对照组61例。两组在常规治疗基础上,治疗组采用复方蓼大青叶口服液治疗,对照组采用利巴韦林喷雾剂治疗。结果:①治疗组平均退热时间(2.8±1.2)d短于对照组(3.9±1.1)d,P<0.01;治疗组退热起效时间(2.1±1.0)d短于对照组(2.9±1.2)d,P<0.01。②体温疗效观察,治疗组总有效率93.5%,对照组总有效率85.2%,咽痛疗效观察,治疗组总有效率95.2%,对照组总有效率为80.3%,P<0.05。③治疗7 d后两组患儿其伴随症状比较,治疗组咳嗽、流涕、鼻塞等症状有效率均多于对照组,P<0.05。结论:复方蓼大青叶口服液治疗儿童急性上呼吸道感染热证具有起效快、疗效好,安全无毒副作用的特点,故可作为治疗儿童急性上呼吸道感染热证的首选药物之一。
Objective: To observe the efficacy and safety of compound Polygonum Daqingye oral liquid in the treatment of acute upper respiratory tract infection in children. Methods: A total of 123 children with acute upper respiratory tract infection were randomly divided into treatment group (n = 62) and control group (n = 61) according to the digital method. The two groups on the basis of conventional treatment, the treatment group treated with compound Daqingye oral liquid, the control group treated with ribavirin spray. Results: ① The mean time to onset of fever in the treatment group (2.8 ± 1.2 days) was shorter than that in the control group (3.9 ± 1.1 days) (P <0.01) 1.2) d, P <0.01. ② The observation of body temperature showed that the total effective rate was 93.5% in the treatment group and 85.2% in the control group. The total effective rate was 95.2% in the control group and 80.3% in the control group (P <0.05). ③Compared with the control group, the effective rate of cough, runny nose and nasal obstruction in the two groups were more than those in the control group after 7 days of treatment (P <0.05). Conclusion: Polygonum multiflorum Oral Liquid for the treatment of acute upper respiratory tract infection in children has the characteristics of quick onset, good curative effect, safe and nontoxic side effects and is therefore considered as one of the first choice drugs for the treatment of acute upper respiratory tract infection in children.