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目的:观察脐血干细胞肝动脉移植治疗慢性肝功能衰竭的临床疗效。方法:40例乙肝慢性肝功能衰竭患者,随机分成治疗组20例,对照组20例,治疗组20例在内科综合治疗的基础上给予脐血干细胞肝动脉移植,每个病人干细胞的回输量均在(2~5)×107/L。对照组20例给予常规内科综合治疗。分别观察治疗前后两组患者一般情况、生化指标的变化。结果:经脐血干细胞肝动脉移植后4~12周患者一般情况明显好转,肝脏合成、代谢、再生等相关指标逐步改善,差异有统计学意义(P<0.05)。结论:通过脐血干细胞肝动脉移植治疗慢性肝功能衰竭患者,在近期内可明显改善临床症状及相关生化指标。
Objective: To observe the clinical efficacy of transplanted hepatic artery of umbilical cord blood stem cells in patients with chronic liver failure. Methods: Forty patients with chronic hepatitis B with chronic hepatitis B were randomly divided into treatment group (n = 20) and control group (n = 20). The treatment group (n = 20) received transplantation of umbilical cord blood stem cells on the basis of comprehensive medical treatment. All in (2 ~ 5) × 107 / L. The control group of 20 cases given conventional internal medicine treatment. Before and after treatment were observed in both groups of general conditions, biochemical changes. Results: The general condition of patients after 4 ~ 12 weeks of transplanted hepatic artery of umbilical cord blood stem cells was obviously improved. The related indexes such as synthesis, metabolism and regeneration of liver gradually improved. The difference was statistically significant (P <0.05). Conclusion: The treatment of patients with chronic liver failure by transplantation of umbilical cord blood stem cells in the hepatic artery can significantly improve clinical symptoms and related biochemical parameters in the near future.