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目的:探讨我院碳青霉烯类抗菌药所致不良反应的特点及相关因素,为临床合理用药提供参考。方法:对我院2008年3月1日~2014年8月1日上报的因使用碳青霉烯类抗菌药出现的不良反应报告进行统计分析。结果:由碳青霉烯类引起的不良反应共73例。发生不良反应的男女例数相当,80岁以上人群发生不良反应例数较多。用药第1天发生不良反应例数较多。不良反应主要为皮肤及其附件损害、神经系统损害。结论:临床应重视碳青霉烯类抗菌药的不良反应,用药时注意患者的临床表现对于肾功能减退、患神经系统基础疾病的患者及时调整用药方案。减少不良反应的危害。
Objective: To investigate the characteristics and related factors of adverse reactions caused by carbapenem antibiotics in our hospital, and to provide a reference for clinical rational drug use. Methods: Statistical analysis was made on the adverse reactions reported by our hospital from March 1, 2008 to August 1, 2014 due to the use of carbapenem antibacterials. RESULTS: A total of 73 adverse reactions were caused by carbapenems. The number of adverse reactions occurred in both men and women fairly, more cases of adverse reactions in people over the age of 80 more. A large number of adverse reactions occurred on the first day of treatment. Adverse reactions mainly damage the skin and its accessories, nervous system damage. Conclusion: Clinical should pay attention to the adverse reactions of carbapenem antibacterial drugs, pay attention to the clinical manifestations of patients with medication for renal dysfunction, patients with underlying diseases of the nervous system to adjust the medication regimen. Reduce the harmful effects of adverse reactions.