目的介绍卵圆细胞的概况及其与原发性肝癌关系的研究进展。方法查阅国内外近年来有关卵圆细胞和原发性肝癌关系的文献并做综述。结果卵圆细胞是一种肝脏干细胞,定位于Hering管。在肝细胞严重受损或分裂增生受抑制时可向肝细胞和胆管上皮细胞分化。近年来研究发现了许多新的卵圆细胞表面标志物,推动了卵圆细胞的识别。卵圆细胞的增生程度与慢性肝病的恶性程度和炎症程度呈正相关,并且参与了肝癌的发生、发展、复发和转移,与肝癌的预后密切相关。结论深入研究卵圆细胞的生物学特性,将为原发性肝癌的诊断、治疗和预防提供新的策略。 Objective To introduce the general situation of oval cells and its relationship with primary liver cancer. Methods The literatures about the relationship between oval cells and primary liver cancer at home and abroad in recent years were reviewed and reviewed. Results Oval cells are a type of hepatic stem cells located in the Hering tube. Hepatocytes and bile duct epithelial cells differentiate when they are severely damaged or their proliferation is inhibited. In recent years, the study found many new oval cell surface markers, promote the oval cell recognition. The degree of oval cell proliferation is positively correlated with the degree of malignancy and inflammation of chronic liver disease, and is involved in the occurrence, development, recurrence and metastasis of hepatocellular carcinoma, which is closely related to the prognosis of hepatocellular carcinoma. Conclusion In-depth study of the biological characteristics of oval cells will provide a new strategy for the diagnosis, treatment and prevention of primary liver cancer.