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目的探讨能动性相关蛋白-1(MRP-1/CD9)和缺氧诱导因子-1α(HIF-1α)在膀胱移行细胞癌中的表达及临床意义。方法采用免疫组化SP法观察46例膀胱癌石蜡标本中MRP-1/CD9和HIF-1α的表达情况,结合临床资料进行分析。结果膀胱癌组织中MRP-1/CD9和HIF-1α的阳性表达率分别为56.5%和43.5%。MRP-1/CD9阳性表达率在复发肿瘤中及随病理分级升高而下降(P<0.05),但与临床分期无关(P>0.05);HIF-1α的阳性表达率在复发肿瘤中及随病理分级、临床分期升高而升高(P<0.05)。MRP-1/CD9和HIF-1α的阳性表达率无显著相关性(P>0.05)。结论MRP-1/CD9和HIF-1α的表达可能是判断膀胱癌生物学行为的重要指标。
Objective To investigate the expression and clinical significance of MRP-1 / CD9 and HIF-1α in bladder transitional cell carcinoma. Methods The expression of MRP-1 / CD9 and HIF-1α in 46 cases of bladder cancer paraffin specimens were observed by immunohistochemical SP method and analyzed with clinical data. Results The positive rates of MRP-1 / CD9 and HIF-1α in bladder cancer were 56.5% and 43.5% respectively. The positive rate of MRP-1 / CD9 expression in recurrent tumors decreased with the increase of pathological grade (P <0.05), but had no correlation with clinical stage (P> 0.05). The positive rate of HIF-1α in recurrent tumors was Pathological grade, clinical stage increased and increased (P <0.05). There was no significant correlation between the positive rate of MRP-1 / CD9 and HIF-1α (P> 0.05). Conclusion The expression of MRP-1 / CD9 and HIF-1α may be an important index to judge the biological behavior of bladder cancer.