论文部分内容阅读
目的:探讨江苏妇女HR-HPV基因型在正常宫颈、癌前病变(CIN I、CIN II、CIN III)和宫颈癌的分布特点及关系,为宫颈癌预防提供理论依据。方法:对2014年12月至2015年12月在我院行宫颈组织病理检查的424例江苏妇女进行HPV分型检测。以病理检查结果为依据,分为正常组、CIN I组、CIN II组、CIN III组、宫颈癌组,运用卡方检验研究江苏妇女HR-HPV感染与不同宫颈病变组的关系。结果:正常组、CIN I组、CIN II组、CIN III组、宫颈癌组的HR-HPV感染率分别为24.3%、50.0%、71.5%、75.9%、82.1%。正常组与各病变组的感染率有统计学差异(P<0.01)。单一型别和多重型别感染率无差异(P=0.973);随着宫颈病变级别增加,HR-HPV分布不同。CIN I组以HPV16、52、58和51最为常见。CIN II/III组以HPV16、58、52、33和31最为常见。宫颈癌组以HPV16、53、18和58最为常见;HR-HPV感染年龄高峰为>49岁,感染年龄低峰为20-29岁(P<0.01)。结论:江苏妇女宫颈病变的严重程度与HR-HPV感染率呈正相关,与感染HPV高危型的数目无关。除了HPV16,HPV58、52、33和31均与宫颈癌和癌前病变密切相关。HR-HPV感染率存在年龄差异,应加强对>49岁江苏女性的重视,定期进行HPV分型检测和宫颈病变筛查。
Objective: To investigate the distribution characteristics and relationships of HR-HPV genotypes in normal cervical and precancerous lesions (CIN I, CIN II, CIN III) and cervical cancer in Jiangsu women and to provide a theoretical basis for the prevention of cervical cancer. Methods: A total of 424 Jiangsu women undergoing cervical histopathology from December 2014 to December 2015 in our hospital were tested for HPV typing. Based on the results of pathological examination, the patients were divided into normal group, CIN I group, CIN II group, CIN III group and cervical cancer group. The relationship between HR-HPV infection and different cervical lesions in Jiangsu women was studied by chi-square test. Results: The HR-HPV infection rates in normal group, CIN I group, CIN II group, CIN III group and cervical cancer group were 24.3%, 50.0%, 71.5%, 75.9% and 82.1% respectively. The infection rate of normal group and each lesion group had statistical difference (P <0.01). There was no difference in single-type or multiple-type infection (P = 0.973). HR-HPV was distributed differently with the increase of cervical lesions. CIN I group with HPV16, 52,58 and 51 most common. The CIN II / III group is the most common with HPV16, 58, 52, 33 and 31. Cervical cancer group was the most common HPV16,53,18 and 58; HR-HPV infection peak age> 49 years, the age of infection was 20-29 years old (P <0.01). Conclusion: The severity of cervical lesions in Jiangsu women is positively correlated with the infection rate of HR-HPV, but not with the number of HPV-infected high-risk type. In addition to HPV16, HPV58, 52, 33 and 31 are closely related to cervical cancer and precancerous lesions. HR-HPV infection rate differences exist, we should strengthen the> 49-year-old Jiangsu women’s attention, regular HPV typing and cervical lesions screening.