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传统口服抗凝药物:华法林和醋硝香豆素口服抗凝药通过抑制维生素K依赖性凝血因子(II、VII、IX和X)以及及蛋白C、蛋白S合成时的γ羧基化过程而发挥药理作用。常通过检测INR来观察抗凝效果。现有的口服抗凝药物中欧洲常用醋硝香豆素,美国常用华法林。两种药物的主要区别在于药物作用的持续时间不同,醋硝香豆素停药后3 d恢复正常凝血功能,而华法林需要5 d。华法林抑制维生素K依赖性凝血因子VII、IX、
Traditional oral anticoagulants: Warfarin and acenocoumarol Oral anticoagulants inhibit the production of vitamin C by inhibiting the vitamin K-dependent clotting factors (II, VII, IX and X) and the gamma-carboxylation of protein C and protein S synthesis And play a pharmacological effect. Often through the detection of INR to observe the anticoagulant effect. The existing oral anticoagulants in Europe commonly used vinegar coumarin, the United States commonly used warfarin. The main difference between the two drugs was the duration of the drug effect, which returned to normal coagulation at 3 days after administration of acenocoumarin, whereas warfarin required 5 days. Warfarin inhibits vitamin K-dependent coagulation factors VII, IX,