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目的观察三水胶囊对大鼠急性脑出血后脑水肿的防治作用。方法将大鼠随机分为假手术组、模型组、安宫牛黄丸组、三水胶囊(高、中、低剂量分别为30、15、7.5 g·kg~(-1))组。于术前3 d至术后8 d给药。用脑内注射自身股动脉血建立大鼠急性脑出血模型,分别采用行为学评分法和干湿质量法,比较各组大鼠的行为学得分和脑组织的含水量。结果从第1天开始至实验结束,模型组大鼠的行为学得分均非常显著地高于假手术组;与模型组比较,第1天、第4天,各给药组大鼠的行为学得分无显著差异;与模型组比较,术后第8天,高、中剂量三水胶囊组大鼠的行为学得分非常显著地降低,低剂量组的显著降低。与假手术组比较,模型组大鼠的脑系数和脑组织中的含水量均非常显著地升高;与模型组比较,高、中剂量三水胶囊组大鼠的脑系数和脑组织中的含水量显著地降低,低剂量组的差异不明显。结论三水胶囊对脑出血水肿有较好的防治作用。
Objective To observe the preventive and therapeutic effects of Sanshui Capsule on cerebral edema after acute intracerebral hemorrhage in rats. Methods The rats were randomly divided into sham-operation group, model group, Angong Niuhuang Wan group and Sanshui capsule (high, medium and low doses were 30,15,7.5 g · kg -1) group. Preoperative 3 d to 8 d after administration. Acute intracerebral hemorrhage was induced in rats by injecting femoral artery with intracerebral hemorrhage. Behavioral score and wet / dry weight were used respectively to compare the behavioral scores and the water content of brain tissue in each group. Results From the first day to the end of the experiment, the behavioral score of the model group was significantly higher than that of the sham-operated group. Compared with the model group, on the 1st day and the 4th day, There was no significant difference between the model group and the model group. On the 8th day after operation, the behavioral scores of the high and middle dose Sanshui capsules groups decreased significantly and the low dose groups decreased significantly. Compared with the sham operation group, the cerebral coefficient and the water content in the brain tissue of the model group increased very significantly. Compared with the model group, the brain coefficients of the rats in the high and medium dose Sanshui capsules and those in the brain tissue Water content decreased significantly, but the difference was not obvious in low dose group. Conclusion Sanshui capsule has a better preventive and therapeutic effect on cerebral hemorrhage and edema.