Chloroform has obvious hepato-,nephro-toxicity and carcinogenicity.In order to getnecessary data for recommendation of maximum allowable concentration of chloroform inworkplace,a series of studies were carried out.The results showed that exposed workersmainly distributed in the industries of perspex processing,production of refrigerants,drugsand pesticides.The exposure level ranged 4.27-147.91 mg/m~3 in 119 air samples collected from3 representive worksites,with 45.4% air samples below 20 mg/m~3.The workers exposed tochloroform at 29.51 mg/m~3 had slight liver damage indicated by the higher rates of abnormalserum prealbumin and transferrin levels than those of control workers.The neurobehavioralfunctions of these workers were also obviously affected,manifested as increases in scores ofpassive mood states and dose-related negative changes in neurobehavioral testing.Theobserved effect threshold concentration of subacute inhalation in rats was 592 mg/m~3according to the observation on the biochemical chang Chloroform has obvious hepato-, nephro-toxicity and carcinogenicity. In order to obtain necessary data for recommendation of maximum allowable concentration of chloroform in workplace, a series of studies were carried out. The results showed that exposed workers mainly distributed in the industries of perspex processing, production of refrigerants, drugs and pesticides. The exposure level ranged 4.27-147.91 mg / m ~ 3 in 119 air samples collected from3 representive worksites, with 45.4% air samples below 20 mg / m ~ 3. The workers exposed tochloroform at 29.51 mg / m ~ 3 had slight liver damage indicated by the higher rates of abnormalserum prealbumin and transferrin levels than those of control workers. Manifested as increases in scores ofpassive mood states and dose-related negative changes in neurobehavioral testing. Theobserved effect threshold concentration of subacute inhalation in rats was 592 mg / m ~ 3according to the observation on the biochemical chang