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目的：研究住院老年患者泌尿系感染病原菌分布及耐药性变迁，为指导临床合理使用抗菌药物提供依据。方法通过病原学标本分离鉴定技术和药敏试验方法，对某医院527例住院老年病人泌尿系感染尿标本进行了监测与分析。结果从527例泌尿系感染的老年患者中段尿中检出病原菌共527株，其中大肠埃希菌占32.1％、铜绿假单胞菌和肠球菌分别为12.7％和12.1％，居前三位。所分离出的革兰阴性杆菌对阿米卡星、头孢他啶、哌拉西林/他唑巴坦、亚胺培南及美罗培南敏感；肠球菌对替考拉宁及万古霉素敏感。已经检出耐万古霉素的屎肠球菌。结论革兰阴性杆菌在老年泌尿系感染中占绝对优势，不同菌种对抗菌药物耐药率差别较大，合理使用抗菌药物对有效控制感染及避免耐药菌株的产生尤为关键。“,”Objective To investigate the urinary tract infection in senile hospitalized patients with bacteria distribution and the change of drug resistance in order to provide the basis for guiding clinical rational use of antibiotics. Methods Separation by etiology specimens identification technology and drug sensitive test method were used to monitor and analyze 527 cases of hospitalized senile urinary tract infection. Results There were 527 strains of pathogens isolated from senile patients with urinary tract infection. E. coli accounted for 32. 1% in the first place. P. aeruginosa and Enterococcus accoun-ted for 12. 7% and 12. 1% respectively. The Gram-negative coccus separated were sensitive to AMK,CAZ,TZP,IPM and MEM. Enterococcus were sensitive to TEC and VA. Conclusion The Gram-negative bacteria were dominant in the urinary tract infection in elder. Different bacteria have different drug resistance. Rational use of antibiotics was very impor-tant to control urinary tract infection and to avoid the generation of drug-resistant strains.