轻度缺碘地区亚临床克汀病的筛查及其流行特征

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新近发现山西省柳林县部分地区属轻度缺碘地区:水碘2.4μg/L,居民尿碘40.3μg/g·Cr,地甲肿患病率8.5%。该地区目前尚未施用碘剂防治。我们于1988年8~11月对该地区土生土长的1012名0~12岁儿童进行亚临床克汀病筛查,发现该地区亚克汀患病率为1.98%,亚克汀患病率随年龄增加而增高,趋势x~2检验有十分显著统计学意义。男女性别之比为1∶1.1。对筛出的20例亚克汀病患者采用1∶1配对调查,发现体重、身高、头围、内眦、外眦、瞳距等躯体发育指标均无明显差异。智能发育方面,亚克汀儿童抬头平均晚一个月,认人平均晚两个月,有显著的统计学意义。 采用相同的程序对缺碘已补碘十年的相邻县临县6个村1028名0~12岁儿童筛查,该县生活条件、文化水平和柳林县极相似,亚临床克汀病患病率为0.68%,与柳林县相比,有十分显著的统计学意义,说明补碘确实是防治亚克汀病的有力措施。 Recently, some areas in Liulin County, Shanxi Province, were found to be mildly iodine-deficient areas: water iodine 2.4 μg / L, urine iodine 40.3 μg / g · Cr, and the prevalence of dendrites and guts 8.5%. Iodine control has not been implemented in the area at this time. We conducted a subclinical cretinism screening test in 1012 children 0-12 years old born and raised in the area from August to November 1988 and found that the prevalence of amikacin in the area was 1.98% Increase and increase, trend x ~ 2 test has a very significant statistical significance. The ratio of male to female is 1: 1.1. 20 cases of clindamycin patients were screened by 1: 1 paired survey and found that body weight, height, head circumference, infants, leprosy, IPD and other physical development indicators were not significantly different. In terms of intelligent development, children aged up to one month after receiving gemcitetine had a statistically significant mean of two months later. The same procedure was used to screen 1028 children aged 0-12 years old in 6 villages in adjacent counties of Linxian county who had been iodine deficiency for iodine deficiency for ten years. The county’s living conditions, education level and Liulin County were very similar, and subclinical cretinism The prevalence was 0.68%, compared with Liulin County, there is a very significant statistical significance, indicating that iodine supplementation is indeed a powerful preventive measures against diabetes.
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