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目的 探讨缺血性卒中患者脑脊液中抗心磷脂抗体（ Ａ Ｃ Ａ） 含量变化的意义及与血浆中 Ａ Ｃ Ａ 含量变化的关系。方法 采用酶联免疫吸附试验（ Ｅ Ｌ Ｉ Ｓ Ａ） 对３４ 例急性脑梗塞病人血浆和脑脊液中 Ａ Ｃ Ａ 含量进行检测，并与２４ 例作为对照组进行比较。结果 脑梗塞组血浆和脑脊液中 Ａ Ｃ Ａ 阳性率明显高于对照组（ Ｐ ＜ ０ ．００５） ； Ａ Ｃ Ａ 分型中，脑梗塞组脑脊液 Ｉｇ Ｇ、 Ｉｇ Ｍ阳性率明显高于对照组（ Ｐ＜ ０ ．０５） ，而血浆各型均与对照组无显著性差异。结论 检测脑脊液 Ａ Ｃ Ａ 含量的敏感性高于血浆，可作为研究 Ａ Ｃ Ａ 与缺血性脑血管病关系的一项可靠指标，对缺血性脑血管病的病理机制研究以及对疾病的预防、治疗和预后判断可能有一定帮助。
Objective To investigate the significance of the change of anticardiolipin antibody (A C A) in cerebrospinal fluid (CSF) in patients with ischemic stroke and its relationship with the changes of A C A in plasma. Methods The contents of A C A in plasma and cerebrospinal fluid of 34 patients with acute cerebral infarction were detected by enzyme-linked immunosorbent assay (ELISA) and compared with 24 as control group. Results The positive rate of A C A in cerebral infarction group was significantly higher than that in control group (P <0 .005). In A C A classification, the positive rate of Ig G and Ig M in cerebrospinal fluid in cerebral infarction group was significantly higher than that in control group P <0 .05), but no significant difference between plasma and control group. Conclusions The detection of A C A in cerebrospinal fluid is more sensitive than that in plasma, which can be used as a reliable indicator to study the relationship between A C A and ischemic cerebrovascular disease. The pathological mechanism of ischemic cerebrovascular disease and its prevention , Treatment and prognosis may have some help in judging.