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目的 :探讨DDp + 5 -Fu诱导化疗在鼻咽癌治疗中的临床意义。方法 :对 82例Ⅲ～Ⅳ期鼻咽癌患者随机分为两组 :诱导化疗组 (诱导化疗 +放疗组 ) 39例 ,对照组 (单纯放疗组 ) 4 3例。诱导化疗组在放疗前先用DF方案化疗 2个周期 ,放疗方案两组相同。结果 :诱导化疗组与对照组 1年局部控制率分别为 97 4%和 81 4% ,1年无远处转移率分别为 97 4%和 83 7% ,两组相比有显著性差异 (P <0 0 5 )。 3、5年局控率 ,无远处转移率及 1、3、5年生存率两组无显著性差异 (P >0 0 5 )。两组中的毒副反应以诱导化疗组为明显 ,但经对症处理后未影响治疗疗程。结论 :DDp + 5 -Fu诱导化疗能够提高晚期鼻咽癌的近期疗效 ,但未能提高其远期疗效。化疗与放疗如何结合应用 ,尚有待进一步研究
Objective: To investigate the clinical significance of DDp + 5 -Fu induced chemotherapy in the treatment of nasopharyngeal carcinoma. Methods: 82 patients with stage Ⅲ ~ Ⅳ nasopharyngeal carcinoma were randomly divided into two groups: induction chemotherapy group (induction chemotherapy + radiotherapy group) 39 cases, control group (radiotherapy group) 43 cases. Induction chemotherapy group before chemotherapy with DF chemotherapy 2 cycles, the same radiotherapy program in both groups. Results: The 1-year local control rates of induction chemotherapy group and control group were 97 4% and 81 4%, respectively. There was 97 4% and 83 7% distant metastasis in one year respectively, there was a significant difference between the two groups (P <0 0 5). There was no significant difference between 3 and 5 years in local control rate, distant metastasis rate and 1,3,5 year survival rate (P> 0.05). Toxic side effects in both groups to induce chemotherapy was obvious, but after the symptomatic treatment did not affect the course of treatment. Conclusion: DDp + 5-Fu induction chemotherapy can improve the short-term efficacy of advanced nasopharyngeal carcinoma, but failed to improve its long-term efficacy. How to combine the application of chemotherapy and radiotherapy remains to be further studied