目的　观察米非司酮 (Ru4 86 )不同服药方式用于孕 16周内计生对象流产的临床疗效。方法　对于合作的计生对象将Ru4 86、米索前列醇 (PGE)以常规方法给药 ;对于不合作对象将Ru4 86 15 0mg顿服 4 8h后给服PGE 0 6mg ;对孕≥ 12周、≤ 16周以内对象另加服PGE 0 4～ 0 6mg并住院观察。 结果　 16～ 30岁与 31～ 4 9岁年龄组其完全流产率分别为 90 2 8%、94 81% (P >0 0 5 )。孕 5 0～ 112d计生对象的常规给药与顿服给药其完全流产率分别为 94 77%、97 6 7% (P >0 0 5 )。孕≤ 4 9d与孕 5 0～ 112d药物流产其完全流产率分别为 93 39%、95 85 % (P >0 0 5 )。结论　两种不同的服药方法 ,对其临床效果影响不大。孕 5 0～112d内的药物流产效果略优于孕 4 9d以内的药物流产效果。 Objective To observe the clinical efficacy of mifepristone (Ru4 86) in different modes of administration for miscarriage in pregnant women within 16 weeks gestation. Methods: Forty-eight patients were enrolled in this study. Ru4 86 and misoprostol (PGE) were administered in the usual way. For uncooperative patients, Ru4 86 150 mg was given for 48 hours and then given PGE 0 6 mg. For pregnant women ≥ 12 weeks, ≤ Subjects within 16 weeks plus PGE 0 4 ~ 0 6mg and hospitalized. Results The complete abortion rates of 16 ~ 30 years and 31 ~ 49 years old group were 90.28% and 94.81% respectively (P> 0.05). The total miscarriage rate of the pregnant women who were born between 50 and 112 days of pregnancy was 94.77% and 97.67%, respectively (P> 0.05). The complete abortion rate of medical abortion ≤ 49 days and pregnancy 0 ~ 112 days were 93 39% and 95 85%, respectively (P 0 05). Conclusion Two different methods of taking medicine have little effect on the clinical effect. The effect of medical abortion within 5 ~ 112 days of pregnancy was slightly better than that of medical abortion within 49 days of pregnancy.