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采用预聚-扩链-中和-分散法合成聚氨酯(PU)水溶液,将PU与淀粉(ST)溶液按照不同质量比进行复合,采用凝聚相分离法制备PU/ST复合微球;用傅立叶变换红外光谱(FTIR)、扫描电子显微镜(SEM)对微球进行表征,并以盐酸四环素为模型药物制备载药复合微球,初步研究了载药PU/ST复合微球的药物释放性能。结果表明,微球的平均粒径为2～3mm,球形光滑圆整,其内部有许多均匀致密、呈辐射状的管状孔隙,此种结构有利于承载药物,说明该材料可作为药物载体材料;载药复合微球的载药量为1.16%,微球包封率为97%,药物稳定释放时间可达25h。
Polyurethane (PU) aqueous solution was prepared by prepolymerization-chain extension-neutralization-dispersion method. PU and ST solution were compounded at different mass ratios. PU / ST composite microspheres were prepared by condensed phase separation. Fourier transform The microspheres were characterized by Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). The drug-loaded composite microspheres were prepared with tetracycline hydrochloride as model drug. The drug release properties of the drug-loaded PU / ST composite microspheres were investigated. The results showed that the average particle size of the microspheres was 2 ~ 3 mm, the sphere was smooth and round, and many uniform and radial tubular pores were formed inside the microspheres. This kind of structure was conducive to drug loading, indicating that the microspheres could be used as drug carrier materials. Drug-loaded composite microspheres drug loading was 1.16%, microspheres encapsulation efficiency was 97%, the drug stable release time of up to 25h.