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3-(四乙酰葡糖六环糖-2-基)-1-(2-氯乙基)-1-亚硝基脲(下简称GCNU)是一个结构与链脲霉素(Streptozotocin)相类似的氨基葡糖氯乙基亚硝脲化合物。GCNU对小鼠L-1210有较好的疗效。用其LD_(10)剂量15毫克/公斤治疗时,可使接种L-1210小鼠的生命时间延长在100%以上,且不引起白细胞减少。用GCNULD_(40)剂量25毫克/公斤给小鼠一次腹腔注射后,第五天的白细胞为9529/立方毫米,较对照组的12740/立方毫米略有减少,但很快恢复正常。与此相反用卡氮芥(BCNU)LD_(10)剂量30毫克/公升及CCNU LD_(20)剂量50毫克/公升治疗时,可使白细胞显著减少,且于给药后第30天尚未恢复到正常值。以GCNU20毫克/公斤腹腔注射后,对小鼠L-1210及十二指肠粘膜的DNA
3- (Tetraacetylglucosan 6-Cyclohexan-2-yl) -1- (2-chloroethyl) -1-nitrosourea (abbreviated GCNU) is a structure similar to Streptozotocin Of glucosamine chloroethyl nitrosourea compound. GCNU mouse L-1210 has a good effect. Treatment with L-1210 at a dose of 15 mg / kg prolonged the lifespan of mice vaccinated with L-1210 by more than 100% and did not cause neutropenia. After a single intraperitoneal injection of 25 mg / kg of GCNULD_ (40) into mice, the fifth day of white blood cells was 9529 cells per cubic millimeter, a slight decrease from 12,740 cells per cubic millimeter of the control group, but soon returned to normal. In contrast, treatment with BCNU LD_ (10) doses of 30 mg / L and CCNU LD_ (20) doses of 50 mg / L resulted in a significant reduction in leukocytes and did not recover to day 30 after dosing Normal value. After intraperitoneal injection of GCNU 20 mg / kg, the DNA of mouse L-1210 and duodenal mucosa