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目的探讨乳腺原发性鳞状细胞癌(PSCC)的临床和病理特征。方法分析5例乳腺PSCC患者的临床特点,肿瘤大体和镜下特征,免疫组化结果,及患者的预后。结果 5例女性患者发病年龄38~78岁,多表现为无痛性乳腺肿块,腋窝淋巴结均无转移。免疫组化:雌激素(ER)、孕激素(PR)与人表皮生长因子受体(HER)2均阴性表达,p63、细胞角蛋白(CK)5/6及高分子量角蛋白(34βE12)均阳性表达。随访4例,1例术后9年死亡,3例随访6~9个月至今情况良好。结论乳腺PSCC有不同于乳腺浸润性导管癌的HE和免疫组化表达特点,确诊需经严格的病理学诊断。
Objective To investigate the clinical and pathological features of primary breast squamous cell carcinoma (PSCC). Methods The clinical features, gross and microscopic features, immunohistochemical findings and prognosis of 5 patients with breast PSCC were analyzed. Results The onset age of 5 female patients was 38-78 years old. Most of them were painless breast masses without metastasis of axillary lymph nodes. Immunohistochemical staining showed that both estrogen (ER), progesterone (PR) and human epidermal growth factor receptor (HER) 2 were negative expression of p63, cytokeratin 5/6 and high molecular weight keratin 34βE12 Positive expression. Four cases were followed up, one case died 9 years after operation and the other 3 cases were followed up for 6-9 months so far. Conclusion Breast PSCC is different from breast invasive ductal carcinoma of HE and immunohistochemical expression characteristics, confirmed by strict pathological diagnosis.