异乳糖是一种还原性双糖,在细菌的代谢过程中有着非常重要的生物学作用.以D-葡萄糖、D-半乳糖为起始原料,探索了异乳糖的多羟基区域选择性偶联与非选择性偶联两条合成路线,其中非选择性偶联路线经五锅反应,总收率高达44%,中间体及目标产物易于分离纯化,适宜于异乳糖的大量制备.中间体及最终产物的结构均通过NMR,HRMS进行表征. Isotreose is a kind of reducing disaccharide, which plays a very important biological role in the metabolism of bacteria.D-glucose and D-galactose are used as raw materials to explore the selective coupling of polyhydroxyl region of isolactose And non-selective coupling two synthetic routes, including non-selective coupling route through the five pot reaction, the total yield of 44%, the intermediate and the target product is easily isolated and purified, suitable for a large number of preparation of lactose. Intermediates and The structure of the final product was characterized by NMR, HRMS.