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本文通过10例泌乳素(PRL)瘤和7例生长激素(GH)瘤,手术摘除前后下丘脑-垂体-甲块腺轴功能的观察,发现不论PRL瘤和GH瘤手术后血清三碘甲状腺原氨酸(T_3)较术前均呈非常显著的降低,前者术前后血清总T_3为93.37±17.45ng/dl和71.57±18.84ng/dl,P<0.01;后者术前后T_3为97.85±27.30ng/dl和71.46±23.99ng/dl,P<0.05。而基值促甲状腺激素(TSH)、总甲状腺素(T_4及游离甲状腺素(FT_4)手术前后两组均无显著变化。促甲状腺素释放激素(TRH)兴奋试验、10例PRL瘤和7例GH瘤中分别有7例和5例呈低弱或无反应,提示手术摘除垂体腺瘤可引起垂体TSH储备及T_3水平的下降。
In this paper, the function of hypothalamic-pituitary-apical gland axis before and after surgical removal was observed in 10 cases of prolactin (PRL) tumors and 7 cases of growth hormone (GH) tumors. It was found that serum triiodothyroglobulin in patients with PRL tumors and GH tumors after surgery. T3 was significantly lower than before surgery. The total serum T3 before and after the surgery was 93.37±17.45 ng/dl and 71.57±18.84 ng/dl, P<0.01; the latter T_3 was 97.85±. 27.30 ng/dl and 71.46±23.99 ng/dl, P<0.05. There were no significant changes in the baseline thyroid stimulating hormone (TSH), total thyroid hormone (T4 and free thyroxine (FT_4) before and after surgery. Thyroid-releasing hormone (TRH) stimulation test, 10 cases of PRL tumors and 7 cases of GH In 7 cases and 5 cases, respectively, the tumor showed weak or no response, suggesting that surgical removal of pituitary adenomas can cause pituitary TSH reserves and T_3 levels decreased.