血管生成(angiogenesis),又称血管新生化(neovasculariza-tion),是指活体组织在已经存在的微血管床上芽生出新的以毛细血管为主的血管系统的过程。目前普遍认为肿瘤生长、侵袭和转移依赖于血管生成,血管生成部分导致肿瘤多药耐药(multidrug resistance,MDR)[1],在肿瘤的病理分? Angiogenesis, also referred to as neovasculariza- tion, refers to the process by which living tissue sprouts a new capillary-predominant vascular system in an existing microvascular bed. It is generally accepted that tumor growth, invasion and metastasis are dependent on angiogenesis and that part of the angiogenesis leads to multidrug resistance (MDR) [1] in tumor pathology,