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本实验通过以胎脑组织移植修复皮层损伤后瘫痪,观察瘫痪大鼠的神经行为学变化。结果表明,移植组织可在宿主中存活,且与宿主脑组织发生部分整合。移植组的神经行为与损伤组比较明显改善。表现为神经学检查反应的正确率上升,在高杆上爬过的间隔数明显增多,且坠落次数明显减少。移植组的神经行为已基本恢复至伤前正常水平。所以,胎脑组织移植物可在宿主中存活,与宿主组织发生整合,并替代受损神经元,从而改善皮层损伤性大鼠的神经行为。
In this study, the fetus was implanted in fetal brain tissue to repair paralysis after cortical injury. Neurobehavioral changes in paralyzed rats were observed. The results show that the transplanted tissue can survive in the host and partially integrate with the host brain tissue. The neurological behavior in the transplantation group was significantly improved compared with the injury group. The correct rate of neurological examination showed an increase in the number of intervals on the high pole climbed significantly increased, and the number of crashes decreased significantly. The neurological behavior of the transplantation group has basically returned to the pre-injury normal level. Therefore, fetal brain tissue grafts can survive in the host, integrate with the host tissue, and replace damaged neurons to improve neuronal behavior in cortical lesioned rats.