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目的针对2009-2011期间亳州市各区县上报市CDC的手足口病临床诊断病例,进行病毒学检测和鉴定,以了解亳州地区手足口病的流行规律,为手足口病的预防控制及诊断治疗提供科学依据。方法临床诊断为手足口病患儿的咽拭子标本384份,应用逆转录聚合酶链反应(RT-PCR)法进行肠道病毒EV71、CoxA16、非EV71、非CoxA16的其它肠道病毒的检测。结果经检测,EV71感染159例,CoxA16感染94例,非EV71、非CoxA16感染29例,EV71合并CoxA16感染79例,EV71合并其它22例,CoxA16合并其它2例,EV71、CoxA16合并其它感染1例。感染的主要病毒种类为EV71病毒,其次为CoxA16病毒,亳州市各县区发病无明显的地域差别;此病的高发季节在春夏季;年龄以1～3岁为主;男性多于女性,但差异无统计学意义。结论引起亳州地区2009-2011年间手足口病的主要病原体为EV71病毒和CoxA16病毒。
OBJECTIVE To investigate the clinical diagnosis of hand, foot and mouth disease in CDC reported by municipal districts and counties in Bozhou City from 2009 to November 2011, to carry out virological examination and identification in order to know the prevalence of hand-foot-mouth disease in Bozhou area and to provide prevention and control of hand-foot-mouth disease and diagnosis and treatment Scientific basis. Methods A total of 384 throat swabs from children with hand-foot-mouth disease were enrolled in this study. The detection of other enteroviruses of EV71, CoxA16, non-EV71 and non-CoxA16 by reverse transcriptase-polymerase chain reaction (RT-PCR) . Results The results showed that there were 159 cases of EV71 infection, 94 cases of CoxA16 infection, 29 cases of non-EV71 non-CoxA16 infection, 79 cases EV71 combined with CoxA16 infection, 22 cases EV71 combined with other cases, CoxA16 combined with other 2 cases, EV71, CoxA16 combined with other infections . The main type of virus infection was EV71 virus, followed by CoxA16 virus. There was no obvious regional difference in the incidence of all counties in Bozhou City. The disease was mainly occurred in spring and summer, with the age of 1 to 3 years old, more men than women The difference was not statistically significant. Conclusion The main pathogens causing hand-foot-mouth disease in Bozhou region during 2009-2011 are EV71 and CoxA16.