丙烯胺类是一类新的抗真菌药物,其作用机理不同于唑类,其中特比萘芬(terbinafine,Lamisil)有杀真菌作用、口服有效。初步资料表明对治疗甲真菌感染也有效。本文是英国用特比萘芬治疗甲真菌病多中心观察的总结。治疗分2组:长程特比萘芬治疗组,剂量为250mg/d 趾甲感染用12月、指甲感染用6月,共103例,完成90例。结果:治疗结束时,真菌学治愈(镜检和培养均阴性),在趾甲感染中为80%,指甲感染为95%,副作用主要为上消化道不适,3例因此而停药;未见其它重要的副作用,尤其未 Acrylamines are a new class of antifungal agents whose mechanism of action is different from that of azoles, with terbinafine (Lamisil) having a fungicidal effect orally. Preliminary data indicate that treatment of onychomycosis is also effective. This article is a summary of multicenter observations of treatment of onychomycosis with terbinafine in the United Kingdom. The treatment was divided into two groups: long-term terbinafine treatment group, a dose of 250mg / d nail infection in December, nail infection in June, a total of 103 cases, 90 cases completed. Results: At the end of treatment, mycology was cured (both microscopy and culture were negative) with 80% infection in nails and 95% infection in nails. The side effects were mainly upper gastrointestinal discomfort, and 3 were discontinued; no other Important side effects, especially not