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观察大厂矿尘在体内实验和体外实验对肺泡巨噬细胞(PAM)的影响。结果表明大厂矿尘对PAM具有细胞毒性且存在一定的剂量效应关系。提示PAM的功能减弱甚至死亡,导致机体的非特异免疫功能减弱,可能有利于肺癌的发生和发展。
To observe the effect of Dafang mine dust on alveolar macrophages (PAM) in vivo and in vitro. The results show that Dachang mine dust on the cytotoxicity of PAM and there is a certain dose-response relationship. Suggesting that the function of PAM weakened or even died, leading to the body’s non-specific immune function weakened, may be conducive to the occurrence and development of lung cancer.