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目的研究鼻神经内分泌癌的正确诊断和治疗,以改善其治疗效果。方法对8例鼻神经内分泌癌作了临床分析总结,8例中男7例,女1例;左侧6例,右侧2例;平均病程2.8月,病变范围广泛。单纯放射治疗2例,综合治疗3例,1例已行化学治疗正待放射治疗和手术治疗,2例未治失访。结果经免疫组化和电镜检查证实为神经内分泌癌,其中小细胞型5例,未分化型2例,低分化型1例。1例1年2个月死亡,2例失访,其余仍在治疗随访中。结论本病进展快,预后差,临床治疗中应采用综合治疗方案,单纯手术疗效差。
Objective To study the correct diagnosis and treatment of nasal neuroendocrine carcinoma in order to improve its therapeutic effect. Methods Eight cases of nasal neuroendocrine carcinoma were analyzed clinically. There were 7 males and 1 females in 8 cases. There were 6 cases on the left and 2 cases on the right. The average course of disease was 2.8 months with a wide range of lesions. Radiotherapy alone in 2 cases, 3 cases of comprehensive treatment, 1 case of chemotherapy has been pending radiotherapy and surgical treatment, 2 cases of lost control. Results Immunohistochemistry and electron microscopy proved to be neuroendocrine carcinomas, including 5 cases of small cell type, 2 cases of undifferentiated type and 1 case of poorly differentiated type. One patient died in 1 year and 2 months, 2 patients lost follow-up, and the rest were still under follow-up. Conclusion The disease progresses rapidly and the prognosis is poor. Clinical treatment should be combined with comprehensive treatment and surgery alone is ineffective.