论文部分内容阅读
血管紧张素Ⅱ (AngⅡ )的生理效应是通过与不同组织浆膜上的受体结合后发挥的 ,其受体具有多种类型。目前已知AngⅡ的主要作用是通过一型受体 (AT1)介导的 ,包括调节肺、肝、脑和肾脏的功能 ,产生血管收缩 ,促进细胞生长和增殖 ,释放激素 ,调节血容量等效应。刺激二型受体 (AT2 )能够拮抗AT1受体的效应。AT2 受体主要存在于胚胎组织及成人的脑组织、肾上腺髓质、子宫和卵巢。其基因定位于X染色体上。主要生物效应是抑制细胞生长、调节细胞程序化凋亡过程 ,参与胎儿生长过程及血管损伤、心肌梗塞后局部组织的结构重构及皮肤损伤修复等作用。并能产生一氧化氮 ,使血管舒张
The physiological effect of angiotensin II (AngⅡ) is exerted by binding to receptors on the plasma membrane of different tissues, and its receptor has many types. It is known that the main role of AngⅡ is mediated by type-1 receptor (AT1), including the regulation of lung, liver, brain and kidney functions, vasoconstriction, cell growth and proliferation, hormone release and blood volume regulation . Stimulation of type 2 receptors (AT2) antagonizes the effects of AT1 receptors. AT2 receptors are mainly found in embryonic and adult brain tissue, adrenal medulla, uterus and ovary. Its gene is located on the X chromosome. The main biological effects are inhibiting cell growth, regulating programmed cell apoptosis, participating in fetal growth process and vascular injury, structural remodeling of local tissues after myocardial infarction, and skin injury repair. And can produce nitric oxide, vasodilation