帕金森病(Parkinson′s disease,PD)又称震颤麻痹,是仅次于阿尔茨海默病的第二常见神经系统变性疾病。除黑质纹状体变性引起的静止性震颤、肌强直及运动迟缓等运动症状外,非运动症状如嗅觉缺失、抑郁、自主神经功能障碍、快动眼睡眠行为异常(rapid eye movement sleep behavior disorder,RBD)及认知损害等也是PD的重要组成部分。随着人口 Parkinson’s disease (PD), also known as Parkinson’s disease, is the second most common degenerative disease of Alzheimer’s disease. In addition to motor symptoms such as rest tremor, myotonia and bradykinesia caused by nigrostriatal degeneration, non-motor symptoms such as loss of smell, depression, autonomic dysfunction, rapid eye movement sleep behavior disorder , RBD) and cognitive impairment is also an important part of PD. With the population