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目的探讨老年慢性心衰患者血清尿酸、尿素氮及凝血功能的关系。方法回顾性分析2012年6月-2014年6月新疆医科大学第一附属医院住院的682例慢性心衰患者的临床资料,根据心功能分级、血尿酸<428μmol/L和血尿酸≥428μmol/L进行分组对比,检验血清尿酸、尿素氮、血浆D-二聚体及纤维蛋白原值。结果老年慢性心力衰竭心功能Ⅲ~Ⅳ级者血尿酸、血尿素氮、D-二聚体及纤维蛋白原水平较心功能Ⅰ~Ⅱ级者明显增加(P<0.05~0.001)。血尿酸≥428μmol/L者血尿素氮、血尿酸D-二聚体、纤维蛋白原水平高于血尿酸<428μmol/L者,差异有统计学意义(P<0.001),病死率也明显增加(P<0.001)。结论慢性心衰患者血尿酸水平随着心功能的增加而升高,且与机体内高凝状态呈正比。
Objective To investigate the relationship between serum uric acid, blood urea nitrogen and coagulation in elderly patients with chronic heart failure. Methods The clinical data of 682 patients with chronic heart failure admitted to the First Affiliated Hospital of Xinjiang Medical University from June 2012 to June 2014 were retrospectively analyzed. According to the classification of cardiac function, serum uric acid <428μmol / L and blood uric acid ≥ 428μmol / L Group comparison, test serum uric acid, urea nitrogen, plasma D-dimer and fibrinogen value. Results The levels of serum uric acid, blood urea nitrogen, D-dimer and fibrinogen in patients with grade Ⅲ ~ Ⅳ of chronic heart failure were significantly higher than those with grades Ⅰ ~ Ⅱ (P <0.05 ~ 0.001). Serum urea nitrogen, serum uric acid D-dimer and fibrinogen were higher than those of blood uric acid <428μmol / L, the difference was statistically significant (P <0.001) P <0.001). Conclusion Serum uric acid levels in patients with chronic heart failure increased with the increase of cardiac function, and was positively correlated with the hypercoagulability in the body.