目的　制备左旋氧氟沙星乳膏 ,建立质量控制方法。方法　以左旋氧氟沙星为主药 ,地塞米松磷酸钠为辅药 ,乳膏基质 4号为赋形剂 ,制备左旋氧氟沙星乳膏。用紫外分光光度计在 2 94nm处测定左旋氧氟沙星的含量 ,建立质量控制方法。结果　其线性范围为 3.2～ 7.2 μg·ml-1,平均回收率为 97.3% ,RSD为 2 .3%。结论　制备方法和质量控制方法简便、快捷、准确 Objective To prepare levofloxacin cream and establish a quality control method. Methods Levofloxacin as the main drug, dexamethasone sodium phosphate as an adjuvant, cream base No. 4 as excipients, preparation of levofloxacin cream. The content of levofloxacin was determined by UV spectrophotometer at 2 94nm, and the quality control method was established. Results The linear range was 3.2-7.2 μg · ml-1 with an average recovery of 97.3% and a RSD of 2.3%. Conclusion The preparation methods and quality control methods are simple, fast and accurate