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目的：研究载脂蛋白Ｂ（ＡｐｏＢ）基因多态性在本地区２型糖尿病患者中的分布及其与血脂的关系。方法：运用聚合酶链反应一限制性片段长度多态性（ＰＣＲ－ＲＦＬＰ）方法检测４１例２型糖尿病患者及６０例正常对照者的ＡｐｏＢ基因型。结果：两组Ｘ＋和Ｅ－等位基因频率分别为０．０８５，０．０１７和０．１１，０．０３３（Ｐ＜０．０１）。糖尿病组血脂总胆固醇（ＣＨ）、甘油三脂（ＴＣ）。低密度脂蛋白胆固醇（ＬＤＬ一ｃｈ）水平均高于对照组（Ｐ＜０、０１）；而高密度脂蛋白胆固醇（ＨＤＬ一ｃｈ）水平低于对照组（Ｐ＜０．０５）。结论；ＡｐｏＢ的Ｘ＋和Ｅ－等位基因可能是２型糖尿病和高脂血症的一个危险因子。
Objective: To study the distribution of apolipoprotein B (ApoB) gene polymorphism in type 2 diabetes mellitus in our region and its relationship with serum lipids. Methods: The ApoB genotypes of 41 type 2 diabetic patients and 60 normal controls were detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: The frequencies of X + and E-allele in two groups were 0.085,0.017 and 0.11,0.033 (P <0.01) respectively. Diabetic group total cholesterol (CH), triglyceride (TC). (LDL-ch) levels were higher than those in the control group (P <0,01), while HDL-cholesterol levels were lower than those in the control group (P <0.05). Conclusion; The X + and E-alleles of ApoB may be a risk factor for type 2 diabetes and hyperlipidemia.