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目的探讨盐酸舍曲林联合美沙拉秦治疗溃疡性结肠炎伴抑郁症患者的临床效果。方法抽取2014年2月-2016年3月温县第二人民医院接收的98例溃疡性结肠炎伴抑郁症患者,根据入院先后顺序分为联合组与单一组,各49例。单一组仅采用美沙拉秦肠溶片,联合组采用美沙拉秦肠溶片+盐酸舍曲林,两组患者均治疗12周。采用SPSS 20.0对数据进行分析,对比两组临床疗效、不良反应发生率及治疗前后抑郁自评量表(SDS)评分和溃疡性结肠炎活动指数(UCAI)变化情况,计量资料用均数±标准差(xˉ±s)表示,采用t检验,计数资料用率(%)表示,采用χ2检验,P<0.05表示差异有统计学意义。结果联合组治疗总有效率为87.76%,单一组为83.67%,组间比较差异无统计学意义(P>0.05);联合组不良反应发生率为6.12%,单一组为8.16%,两组对比差异无统计学意义(P>0.05);治疗前两组SDS及UCAI评分对比差异无统计学意义(P>0.05)。经治疗,两组各指标评分均较治疗前显著改善,差异有统计学意义(P<0.05),且联合组SDS评分明显优于单一组,差异有统计学意义(P<0.05)。结论联合采用盐酸舍曲林和美沙拉秦治疗溃疡性结肠炎伴抑郁患者效果显著,可有效改善其临床症状及抑郁状态,且不会增加不良反应发生率,具有一定安全性。
Objective To investigate the clinical effects of sertraline hydrochloride combined with mesalazine in the treatment of patients with ulcerative colitis and depression. Methods A total of 98 patients with ulcerative colitis and depression who were admitted to Wenxian Second People’s Hospital from February 2014 to March 2016 were selected and divided into the combined group and the single group according to the order of admission. In the single group, mesalazine enteric-coated tablets were used only. The combination group was mesalazine enteric-coated tablets + sertraline hydrochloride, and both groups were treated for 12 weeks. The data were analyzed by SPSS 20.0. The clinical efficacy, the incidence of adverse reactions, the SDS score and the UCAI of the two groups were compared. The measurement data were expressed as mean ± standard Difference (xˉ ± s) that the use of t test, count data with the rate (%) that the use of χ2 test, P <0.05 said the difference was statistically significant. Results The total effective rate was 87.76% in the combined group and 83.67% in the single group, with no significant difference between the two groups (P> 0.05). The incidence of adverse reactions in the combination group was 6.12% and in the single group was 8.16% There was no significant difference between the two groups (P> 0.05). There was no significant difference in SDS and UCAI scores between the two groups before treatment (P> 0.05). After treatment, the score of each index of both groups was significantly improved compared with that before treatment, the difference was statistically significant (P <0.05), and the combination group SDS score was superior to single group, the difference was statistically significant (P <0.05). Conclusion Combined treatment with sertraline and mesalazine for the treatment of patients with ulcerative colitis and depression is effective, which can effectively improve the clinical symptoms and depression, and will not increase the incidence of adverse reactions, with a certain degree of safety.