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目的:探讨宫颈鳞癌组织中Ki-67和P53蛋白的表达及其与临床病理特征的关系。方法:采用免疫组织化学技术,检测60例子宫颈鳞癌、40例宫颈原位癌(CINⅢ)和20例癌旁正常宫颈上皮(NCE)中Ki-67和P53的表达,分析其表达与宫颈鳞癌的临床分期、病理类型及有无淋巴结转移的关系。结果:Ki-67在宫颈鳞癌、原位癌和NCE中的阳性表达率分别为78.33%、52.50%、35.00%;P53为71.67%、55.00%、0.00%。NCE组与鳞癌组及原位癌组相比较差异均有统计学意义(P<0.01)。Ki-67和P53的阳性表达率与临床分期、病理类型及有无淋巴结转移均有明显相关性(P<0.01);Ki-67和P53在宫颈鳞癌的表达中呈正相关(P<0.01)。结论:Ki-67和P53在宫颈癌组织中表达水平的上调可能在宫颈鳞癌浸润和转移中起重要作用。
Objective: To investigate the expression of Ki-67 and P53 in cervical squamous cell carcinoma and its relationship with clinicopathological features. Methods: The expressions of Ki-67 and P53 in 60 cases of cervical squamous cell carcinoma, 40 cases of cervical carcinoma in situ (CINⅢ) and 20 cases of normal cervical epithelium (NCE) were detected by immunohistochemical staining. Cancer staging, pathological type and lymph node metastasis. Results: The positive expression rates of Ki-67 in cervical squamous cell carcinoma, carcinoma in situ and NCE were 78.33%, 52.50% and 35.00%, respectively. P53 was 71.67%, 55.00% and 0.00% respectively. There was significant difference between NCE group and squamous cell carcinoma and carcinoma in situ (P <0.01). The positive rates of Ki-67 and P53 were significantly correlated with the clinical stage, pathological type and lymph node metastasis (P <0.01), but Ki-67 and P53 were positively correlated with the expression of P53 in cervical squamous cell carcinoma (P <0.01) . Conclusion: The upregulation of Ki-67 and P53 expression in cervical cancer may play an important role in the invasion and metastasis of cervical squamous cell carcinoma.